IgA deficiency during penicillamine treatment.

IgA deficiency during treatment of infantile hypothyroidism with thyroxine.

Serum IgA concentrations in five children with infantile hypothyroidism fell soon after the start of treatment with thyroxine. In one child the IgA concentration fell appreciably (to less than 0.01 g/1) and remained reduced; in the four others it returned to normal. IgM and IgG concentrations were roughly normal throughout. The deficiency in IgA concentrations may have been due to stimulation b...

Dermatomyositis complicating penicillamine treatment.

A case of dermatomyositis developing during the course of treatment with D-penicillamine in a patient with rheumatoid arthritis is described. Complete remission occurred on withdrawal of the drug. Possible alternative diagnoses are discussed.

Syndrome with IgA Deficiency

Autosomal deletion syndromes are of great interest since measurable loss of genetic material could lead to the mapping of the human autosomes. Short arm deletions and long arm deletions of chromosome 18 have been described in association with phenotypic changes (Grouchy et al., 1963, 1964) and reviewed recently by Wolf et al. (1967) and Reinwein, Ritter, and Wolf (1967). Since a ring chromosome...

Spondyloarthropathies and IgA deficiency.

IgA deficiency and neutropenia

That the anuria was apparently painless yet due to bilateral obstruction of the ureters by calculi is noteworthy. Herring,4 in a study of 10 000 urinary calculi, found only 89 to contain cystine, of which about 700,, were composed of pure cystine, as in our case. Thus urinary tract calculi may be due to cystinuria even in a young child. Cystinuria5 is a recessive or incompletely recessive genet...